Mimicking Apoptosis using Asymmetric Liposomes: A Therapeutic Approach Against Hiv-1 Infection

Therapeutic vaccines against HIV infection.

Resistance to medication, adverse effects in the medium-to-long-term and cost all place important limitations on lifelong adherence to combined antiretroviral therapy (cART). In this context, new therapeutic alternatives to 'cART for life' in HIV-infected patients merit investigation. Some data suggest that strong T cell-mediated immunity to HIV can indeed limit virus replication and protect ag...

Modern biotechnology-based therapeutic approaches against HIV infection.

The causative agent of acquired immune deficiency syndrome (AIDS) is human immunodeficiency virus (HIV). Since its discovery before 30 years, a number of drugs known as highly active antiretroviral therapy have been developed to suppress the life cycle of the virus at different stages. With the current therapeutic approaches, ending AIDS means providing treatment to 35 million individuals livin...

Response: HIV-2 and Natural Protection Against HIV-1 Infection.

Apoptosis as a Potential Target in Therapeutic and Vaccine Interventions against Parasitic Diseases

Apoptosis is a physiological cell death that occurs under normal conditions in major biological processes, including the removal of old, damaged, extra, or harmful cells. It plays an important role in natural evolution, tissue homeostasis, removal of cells damaged or infected by viruses, and removal of immune cells activated against self-antigens. The purpose of this review was to examine the r...

Therapeutic effects of hybrid liposomes on gastric carcinoma involve apoptosis.

Hybrid liposomes (HLs) composed of 90 mol% dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(23)dodecyl ether (C(12)(EO)(23)), having a hydrodynamic diameter under 100 nm, were preserved for a period of one month. The inhibitory effects of HLs on the growth of gastric carcinoma (CoRa 622 G6) cells in vitro were investigated. Decrease in mitochondrial membrane potential and activ...